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Riociguat (Adempas): Side Effects, Uses, Interaction and Precautions

Riociguat (Adempas) Drugs and Medication


BRAND NAME(s)— Adempas

DRUG CLASS— Soluble Guanylate Cyclase Stimulators

What is Riociguat?

Riociguat is a medication used to treat two types of pulmonary hypertension (PH) — chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Riociguat belongs to a group of drugs called sGC stimulators.

How To Use Riociguat?

Follow all the directions mentioned on the prescription label. Use the medication exactly as directed by your doctor.

You may take Riociguat with or without meal. Store at room temperature away from moisture and heat.


Tell your doctor about all your medications you are currently taking, especially [Trusted Source 1] [Trusted Source 2] [Trusted Source 3]

  • Aminophylline
  • Tobacco smoking
  • Some prescription medications
  • Cytochrome inhibitors
  • Liver enzyme CYP3A4
  • Some vitamins and herbal products
  • Certain drugs to treat chest pain or high blood pressure such as nitroglycerin, isosorbide
  • Dipyridamole
  • Drugs to treat erectile dysfunction such as sildenafil, tadalafil, vardenafil
  • Poppers containing amyl or butyl nitrite, theophylline
  • Nitrates and phosphodiesterase inhibitors (including PDE5 inhibitors)


Before taking this medication, tell your doctor or health care provider if you are allergic to it or if you have a history of any other allergy. [Trusted Source 2] [Trusted Source 3]

Before using Riociguat, tell your doctor about your medical history, especially of [Trusted Source 2] [Trusted Source 3]

  • If you smoke
  • Low or high blood pressure
  • A severe loss of body water (dehydration)
  • Other lung conditions such as idiopathic interstitial pneumonia and pulmonary veno—occlusive disease

It is not clear whether this medication passes into the breast milk. Ask your doctor if you are breast—feeding.

The medication should not be used during pregnancy. It may harm an unborn baby or cause birth defects. Tell your doctor, if you are pregnant or planning to get pregnant. [Trusted Source 2]

Riociguat Side Effects:

Common side effects may include [Trusted Source 2] [Trusted Source 3]

  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Dizziness
  • Indigestion
  • Swelling in your hands, legs, or feet

Stop using Riociguat and call your doctor if you have [Trusted Source 2] [Trusted Source 3]

  • Unusual bleeding from the vagina
  • Coughing up blood
  • Bleeding around catheter site
  • Black or bloody stools
  • Vomit that contains blood or looks like coffee grounds
  • Severe headache
  • Vision problems
  • Slurred speech
  • Low red blood cells (anemia)— unusual tiredness, pale skin, cold hands and feet or shortness of breath

What Should I Avoid While Taking This Medication?

  • It is advisable not have unprotected sex while taking Riociguat medication. For this, you must use birth control or contraceptive pills to prevent pregnancy during treatment and for at least 30 days after you stop taking this medication
  • Smoking can make this medicine less effective. Tell your health care provider if you start or stop smoking while you are taking Riociguat
  • Some antacids can make it harder for body to absorb Riociguat. So you just need to avoid taking this within 1 hour before or 1 hour after you take riociguat

What Happens If I Missed A Dose of Riociguat?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at the same time.

What Happens If I Overdose?

Seek emergency medical help or call the Poison Help line at 1—800—222—1222.


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