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Juluca (Dolutegravir, Rilpivirine): Side Effects, Dosage, Uses, Interaction and Precautions

Juluca Medication and Drugs

GENERIC NAME— Dolutegravir, Rilpivirine

DRUG CLASS— HIV, Integrase Inhibitors; HIV, NNRTIs

BRAND NAME(s)— Juluca

What Is Juluca?

Dolutegravir / Rilpivirine is medication used to treat HIV/AIDS. It helps to reduce the amount of human immunodeficiency virus (HIV) in the body so that the immune system can function better. Dolutegravir is an integrase inhibitor whereas Rilpivirine is a non—nucleoside reverse transcriptase inhibitor (NNRTI). Both medications can block the growth of the virus but not a fully cure for HIV infection.

Juluca Dosage:

Recommended Dosage of Juluca:

One tablet taken orally once daily with a meal. One tablet of Juluca contains about 50 mg of Dolutegravir and 25 mg of Rilpivirine.


Tell your doctor or health care provider about all your current medicines. Many drugs can interact with this medication, especially —


HIV Medication

Before taking this medicine, tell your doctor if you are allergic to Dolutegravir or rilpivirine or if you have a history of any other allergy.

Before using this medication, tell your doctor about the medical history, especially of —

Tell your doctor if you are pregnant or planning to get pregnant. It can harm an unborn baby. Ask your doctor before you start this medication.

It is not clear whether the medication passes into the breast milk. Consult your doctor if you are breast—feeding.

What Are The Side Effects Of Juluca?

Common side effects may include —

  • Diarrhea
  • Headaches

Call your doctor or health care provider if you have —

  • Anxiety
  • Suicidal thoughts
  • Sadness or feeling hopelessness
  • Liver problems — loss of appetite, nausea, vomiting, right—sided upper stomach pain, dark urine, jaundice, clay—colored stools

Dolutegravir and rilpivirine may affect immunity system, which may cause certain side effects. Tell your doctor or health care provider if you have —

  • Fever
  • Night sweats
  • Swollen glands
  • Cold sores
  • Cough
  • Menstrual changes
  • Infertility or impotence
  • Wheezing
  • Weakness
  • Diarrhea
  • Weight loss
  • Trouble speaking or swallowing
  • Problems with balance or eye movement
  • Swelling in the neck or throat (enlarged thyroid)

What Happens If I Missed A Dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost the time of your next scheduled dose. Do not take extra medicine to make up the missed dose.

What Happens If I Take An Overdose?

Seek emergency medical help or call the Poison Help line at 1—800—222—1222.

What Should I Avoid While Taking Juluca?

Juluca medication doesn’t prevent you from passing HIV to other individuals.

To reduce the risk of spreading human immunodeficiency virus (HIV) to others, do all of the following —

  • Continue to take all HIV medications exactly as prescribed by your doctor
  • Always use an effective barrier method such as latex or polyurethane condoms or dental dams during all sexual activity
  • Do not share personal items such as syringes, needles, razors and toothbrushes that may have contacted blood or other body fluids

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