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Dolutegravir : Dosage, Uses, Interaction and Side Effects

Dolutegravir Drugs and Medication

GENERIC NAME— Dolutegravir

BRAND NAME(s)— Tivicay

OTHER NAME(s)— GSK572, S-349572

What Is Dolutegravir?

Dolutegravir (DTG) is an antiretroviral medication used together with other medication to treat HIV/AIDS. Dolutegravir is not a fully cure for HIV/AIDS. It is taken by mouth.

Tivicay is approved for children of age at least 12 years and older weighing at least 40 kilograms. Dolutegravir was approved for medical purpose in the United States in 2013. [Trusted Source 1]

How To Use

This medication is taken by mouth with or without food usually 1 to 2 times daily or as directed by your doctor. [Trusted Source 3]

Its doses are based on weight in children. Your child’s dosage needs may change if the child gains or loses weight. You may need frequent blood tests, while using Dolutegravir medication. [Trusted Source 3]


Tell your doctor about all your current medications before you start using Dolutegravir. Some medicines may interact with Dolutegravir and can make it less effective when taken at the same time. Such medication and products may include [Trusted Source 2]

  • Dofetilide 
  • Orlistat
  • Herbal products
  • Some prescription medications
  • Buffered medicines
  • Ulcer medication such as Sucralfate
  • Vitamin or mineral supplements that contain iron or calcium
  • Antacids or laxatives that contain magnesium, calcium, or aluminum such as Milk of Magnesia, Mylanta, Amphojel, Di-Gel Maalox, Pepcid Complete, Rulox, Rolaids or Tums


Before taking this medicine, tell your doctor if you are allergic to it or if you have a history of any other allergy.

Before taking Dolutegravir medication, tell your doctor about your medical history, especially of [Trusted Source 2]

Tell your doctor if you are pregnant or planning to get pregnant. It may harm an unborn baby. Ask your doctor for more details. [Trusted Source 1] [Trusted Source 3]

It is not clear whether this medication passes into the breast milk. If you are breast feeding, first consult your doctor. [Trusted Source 1] [Trusted Source 3]

What Are The Side Effects Of Dolutegravir?

Common side effects may include —

  • Headaches
  • Feeling tired
  • Sleep problems such as insomnia

Call your doctor or health care provider if you have —

  • The first sign of any skin rash, no matter how mild
  • Liver problems — loss of appetite, upper stomach pain, nausea, vomiting, jaundice, dark urine, clay—colored stools

Dolutegravir affects human immunity system, which may cause certain side effects. Tell your doctor if you have [Trusted Source 2] [Trusted Source 3]

  • Weakness or prickly feeling
  • Swelling in your neck or throat
  • Menstrual changes
  • Infertility or impotence
  • Trouble speaking or swallowing
  • Problems with balance or eye movement
  • Signs of a new infection — fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss

What Happens If I Missed A Dose?

Take Dolutegravir as soon as you can remember. Skip the missed dose if it is almost the time for next dose. Do not take two doses at the same time.

What Happens If I Take An Overdose Of Dolutegravir?

Seek emergency medical help or call the Poison Help line at 1—800—222—1222.

What Should I Avoid While Using Dolutegravir?

Dolutegravir medication doesn’t prevent you from passing HIV to other individuals.

To reduce the risk of spreading human immunodeficiency virus (HIV) to others, do all of the following —

  • Continue to take all HIV medications exactly as prescribed by your doctor
  • Always use an effective barrier method such as latex or polyurethane condoms or dental dams during all sexual activity
  • Do not share personal items such as syringes, needles, razors and toothbrushes that may have contacted blood or other body fluids


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